киров россия новости - 18-04-19

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Специалисты из США, Германии и Великобритании исследовали так называемый комплекс NACA. Было установлено, что он препятствует формированию белковых агрегатов, характерных для нейродегенеративных недугов в вроде болезни Альцгеймера, Гентингтона и спиноцеребеллярной атаксии, передают "Известия".

Было установлено: функция NACA (комплексного альфа-полипептида, связанного с возникающим полипептидом) - восстановление правильной структуры белков и ликвидация соединений с дефектной структурой. Комплекс находит белки, склонные к образованию отложений. Среди них - белки, имеющие в составе полиглутамин (PolyQ) и бета-амилоид, как известно, создающие основу опасных отложений в мозге.

Таким образом, комплекс не дает сформироваться токсичным отложениям и предотвращает повреждения головного мозга. Как показали тесты с мышами, клетки животных, имеющие низкое содержание комплекса NACА, демонстрировали активное образование формы PolyQ. Итогом становилось развитие нейродегенеративных процессов. Получается, NACА - отличная терапевтическая мишень.

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