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Isotretinoin belongs to a group of medicines known as retinoids, which are substances related to vitamin A. It is used to treat acne which is severe, or which has not got better with other treatments such as oral antibiotics or skin treatments Isotretinoin (13-cis retinoic acid) is a vitamin-A derivative (retinoid). The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically. Isotretinoin was developed in the 1950s, but only started being used in the mid 1970s.
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