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Storage. Store the medicine at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Keep all drugs away from reach of children and pets.
Directions. Take Leukeran exactly as prescribed by your doctor. Take this medication by mouth. Drink plenty of fluids while taking this medication to prevent side effects. For chronic lymphocytic leukemia, the usual adult starting dose is 0.15 mg per kilogram body weight per day until the total white blood cell count reaches the desired range. 4 weeks after the first course of treatment, the medication may be restarted at a dose of 0.1 mg per kilogram body weight per day. For Hodgkin's disease, the usual dose is 0.2 mg per kilogram body weight per day for 4 to 8 weeks. For non-Hodgkin's lymphoma, the usual dose is 0.1 mg to 0.2 mg per kilogram body weight per day for 4 to 8 weeks initially.
Drug interactions. Tell your doctor about all other medications you use, especially: live vaccines (mumps, measles, yellow fever), natalizumab, phenylbutazone, pimecrolimus, roflumilast. Interaction between two medications does not always mean that you must stop taking one of them. Tell your doctor or prescriber about all prescription, over-the-counter, and herbal medications you are taking.
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General information. Leukeran belongs to the group of medications known as antineoplastics. It contains chlorambucil. This medication works by preventing the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells. Leukeran is used to treat certain types of cancer (leukemia, lymphoma, Hodgkin's disease). This drug may also be used for certain blood diseases, certain types of kidney disease in children that have not responded to other treatment.
Possible side effect. Get emergency medical help if you have changes in menstrual period, diarrhea, nausea, vomiting, muscle twitching, seizures, skin rash, tremors, unexpected bleeding, difficult urination, unusual tiredness, yellow eyes or skin, black or bloody stools, hives, difficulty breathing, swelling of the throat, mouth, joint pain, pale skin, stomach pain, loss of appetite, dark urine, sore throat, weakness, severe dizziness. If you notice other effects not listed above, contact your doctor.
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